【特別講演2】How to conduct large scale randomised trials: tranexamic acid for severe bleeding.

【企画趣旨】

In 1984, the clinical epidemiologists Salim Yusuf and Rory Collins and the eminent statistician Sir Richard Peto, published a seminal paper in Statistics in Medicine entitled “Why do we need some large simple randomised trials?” They argued that large simple trials of the effects on death of widely practicable treatments for common problems are both possible and essential. They pointed out that most treatment effects will be moderate and so to detect these moderate treatment effects we must avoid moderate bias with proper randomisation and avoid moderate random error by having a large sample size. For 30 years, my research team at the London School of Hygiene and Tropical Medicine has followed their recommendation by conducting large scale clinical trials of widely practicable treatments for acute severe bleeding leading to the identification of tranexamic acid as a highly effective and lifesaving treatment. In this lecture I will discuss how to conduct global clinical trials.

【演者】

• 
  Ian Roberts

略歴：

Ian Roberts is Professor of Clinical Epidemiology at the London School of Hygiene & Tropical Medicine. He trained as a paediatrician in the UK and then in epidemiology at the University of Auckland, New Zealand and McGill University, Canada. He is a clinical academic who works collaboratively with health professionals world-wide to conduct large multi-centre clinical trials aimed at improving patient outcomes in life threatening emergencies. He works with others to build global research partnerships to answer questions together that could not be answered by anyone working alone. He has played lead roles in several large trials including the CRASH trials and the Woman trials.

【座長】

• 
  濱口 杉大

略歴：

新潟大学医学部卒、天理よろづ相談所病院にて初期臨床研修、市立舞鶴市民病院にて総合内科（GIM）研修、関西医科大学にて心療内科研修。その後約６年間、北海道の離島を含む僻地で地域医療に従事。2006年からロンドン熱帯医学衛生大学院校で臨床感染症と熱帯医学を学び、熱帯医学修士課程を修了し、2007年から北海道江別市立病院にて総合内科と研修システムを立ち上げる。長崎大学熱帯医学博士課程を修了。2016年10月から福島県立医科大学総合内科。同大学臨床研究イノベーションセンター副センター長兼務。2024年４月から現職。
高齢者医療（肺炎、予後予測、QOL、DNARなど）、脊椎炎（診断精度）などの現場のニーズに応じた臨床研究に携わっている。
日本内科学会総合内科専門医、日本感染症学会感染症専門医、日本老年医学会老年科専門医、米国内科学会上級会員（FACP）